You might be wondering, what are cannabinoid receptors? There are also plant cannabinoids that are found in cannabis (THC and CBD are. Cannabinoid receptor sites are located throughout the entire body and allow cannabinoids to affect the body. CBD acts upon CB1 and CBD2 receptors located throughout the body to produce a To date, experts agree there are two types of cannabinoid receptors;.
CBD And Cannabinoid Receptors
Although they have similar sounding names, these two receptors perform very different functions in the human body. CB1 receptors first discovered in exist in high numbers in the brain especially the hypothalamus, hippocampus, and amygdala , central nervous system CNS , intestines, connective tissues, gonads, and various other glands. While these are desirable effects for most people, CB1 receptor activation does not come without risks. Please note that these are most often side effects associated with chronic consumption of a potent CB1 receptor agonist such as THC, and not with a non-psychoactive substance such as CBD.
CB2 receptors first discovered in occur most commonly in the spleen, tonsils, thymus, and immune cells such as mast cells, monocytes, macrophages, B and T cells, and microglia; only a small number exist in the brain.
Changes in CB2 receptor function is synonymous with virtually every type of human disease; be it cardiovascular, gastrointestinal, neurodegenerative, psychiatric, and autoimmune. It even plays a role in liver and kidney function, bone and skin health, cancer, and even pain-related illnesses.
The human body does produce cannabinoids. Endogenous Cannabinoids are neurotransmitters produced within our bodies that bind to cannabinoid receptors in the brain, immune system, and elsewhere. Endocannabinoids perform differently to the more well-known neurotransmitters like serotonin, dopamine, and norepinephrine. Dopamine, for example, is synthesized in advance, stored in the vesicle, and in response to stimuli, is released from the presynaptic cell, where it crosses the synapse, lands on the postsynaptic cell, and causes activation.
Endocannabinoids, on the other hand, are key components of cellular membranes that we manufacture on demand. Since endocannabinoids are hydrophobic, they cannot travel very far in the body and so their effects are localized. Endocannabinoids also travel in the opposite direction to other neurotransmitters. They first leave the postsynaptic cell and end at the presynaptic cell where there are high concentrations of axons.
Axons are responsible for the release of traditional neurotransmitters. This allows the postsynaptic cell to control the flow of neurotransmitters coming from the presynaptic cell. Instead, many of the therapeutic benefits of CBD are created through indirect actions. These receptors are involved in regulating pain, body temperature, and inflammation. This inhibition creates higher levels of endocannabinoids like anandamide.
It also performs other important functions like regulating feeding behaviors and assisting with embryo implantation during the early stages of pregnancy. For example, the medical community has already identified that THC can be an effective treatment for multiple ailments, including the side effects of chemotherapy. Because CBD inhibits the negative effects of THC, there is a possibility that administering the two together could be more beneficial than supplementing with THC alone.
Because CBD stimulates the endocannabinoid system, it helps to promote homeostasis in the body, reducing the sensation of pain and inhibiting inflammation. Additional research showed that phytocannabinoids affect these same receptors.
Cannabinoid receptor sites are located all throughout the body, from the brain to the connective tissue. Cannabinoids bind to these sites in order to promote the proper physiological function of the muscular system, immune system, nervous system and more. When considering the effects of phytocannabinoids like cannabidiol, two primary cannabinoid receptors are of interest: Cannabinoid receptor type 1 is found primarily in the central nervous system, although some of these receptors are also present in the peripheral tissues, including the endocrine glands, spleen, heart and other locations.
CB1 receptors are G protein-coupled receptors. Cannabinoid receptor type 2 is found only in peripheral tissues and is not typically found in the central nervous system.
Together, CB1 and CB2 are responsible for regulating neuro-hormones in the body. These receptors have an active role in many different physiological processes, including memory, mood, sensations of pain and appetite regulation. When cannabinoids are introduced to the receptors, either from within the body or from external sources, the receptors activate and produce physiological changes.
Research regarding the direct effects of various phytocannabinoids on the body's specific cannabinoid receptors is ongoing. However, scientists have already learned that certain cannabinoids, such as THC, bind directly with a specific type of receptor.
Cannabidiol , on the other hand, does not bind directly with either CB1 or CB2 receptors. Instead, it stimulates both types of receptors.
CBD (Cannabidiol): What Does It Do & How Does It Affect the Brain & Body?
The scientific literature has identified more than 65 molecular targets of CBD. Although CBD has little binding affinity for either of the two cannabinoid receptors . We aim to define several potential roles of cannabinoid receptors in the several phytocannabinoids, especially cannabidiol (CBD), have. Although there is no doubt that Δ9-THC and CBD can target both.