SIADAP FAQFreu mich auf eure antworten. Ansonsten ist NAC ne gute Idee. Eigene Erfahrung die ich gemacht habe: Referenz sind auch kcal am Tag. Hahaha waren eh noch nie.
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Freu mich auf eure antworten. Ansonsten ist NAC ne gute Idee. Eigene Erfahrung die ich gemacht habe: Referenz sind auch kcal am Tag. Hahaha waren eh noch nie. So lang das Bili nicht steigt Wenn Du gelb wirst,solltest Du ne Pause machen,aber nach 6 Wochen Methas passiert da noch nicht viel. Diese Leberschutz durch Mariendiestel etc. Ist wohl eher im Bereich der Mythen welche die Supp.
Gibt auch keine studien hierzu die es beim mensch belegen. Ursodeoxycholic acid UDCA is a chemical called a bile acid. It occurs naturally in bile and can be used to dissolve gallstones. The liver produces bile that is stored in the gall bladder. Bile is released by the gall bladder to aid the digestion of fats. It consists of cholesterol dissolved within bile salts. Gallstones occur in the gall bladder as a result of too much cholesterol, or too few bile salts within the bile. The imbalance causes excess cholesterol to separate out of the bile and form stones.
Ursodeoxycholic acid causes gallstones to dissolve by a mechanism that is not fully understood. It is known to reduce the production of cholesterol by the liver and also to reduce the absorption of cholesterol from the gut.
Both of these actions decrease the amount of cholesterol that passes into the bile. Also, since ursodeoxycholic acid is a bile acid itself, it increases the level of bile acids within the bile. The combination of these two factors reverses the imbalance and stops the cholesterol separating out of the bile.
The gallstones then begin to dissolve. Besides existing in its natural form, UDCA has been synthesized, and all pharmaceutical formulations are synthetic. Oral 17 alpha alkylated steroids often cause a condition called cholestasis. Cholestasis is any condition in which bile excretion from the liver is blocked, which can occur either in the liver where bile is formed, or in the bile ducts. Extrahepatic cholestasis -- which occurs outside the liver -- can be caused by bile duct tumors, strictures, cysts, diverticula, and other damage.
Other potential causes for this type include stones in the common bile duct, pancreatitis, pancreatic tumor or pseudocyst, primary sclerosing cholangitis, and compression due to a mass or tumor on a nearby organ. Intrahepatic cholestasis -- which occurs inside the liver -- can be caused by sepsis generalized infection , bacterial abscess, drugs, total parenteral nutrition being fed intravenously , lymphoma, tuberculosis, sarcoidosis and amyloidosis.
Other causes of this form of the disorder include primary biliary cirrhosis, primary sclerosing cholangitis, viral hepatitis A,B,C, etc. Often times a panel of standard liver function tests will show cholestasis before the symptoms even manifest themselves, but in general laboratory tests have limited diagnostic value. Transaminase ALT, AST , alkaline phosphate, and bilirubin levels are typically elevated in proportion to the severity of the disease.
AST and ALT can be elevated by exercise, so those are not particularly helpful in diagnosing cholestasis 1. It is intrahepatic cholestasis caused by drugs i. It has been proposed that oral steroids interfere with the pump that exports bile out of liver cells.
UDCA exerts a number of therapeutic effects which prevent and treat cholestasis. For instance, we mentioned the bile transport pump.
UDCA has been shown to stimulate enzymes that increase the density of these bile transporters, allowing bile to exit the liver more readily 2,3. UDCA also protects hepatocytes liver cells against bile induced apoptosis programmed cell death 2.
Quoting from one study,. For 80 days, until 3 weeks before hospitalization, he had been taking moderately high doses of anabolic steroids: Physical examination was unremarkable except for yellow discoloration of the skin and sclerae Liver biopsy was compatible with cholestasis induced by anabolic steroids The patient's state improved simultaneously with the administration of ursodeoxycholic acid and the biochemical values gradually reached normal levels after several weeks.
Anabolic steroids can cause severe cholestasis and acute renal failure. In this case there was a notable temporal coincidence between the administration of ursodeoxycholic acid and the marked clinical improvement.
Interestingly, there seems to be a genetic disposition to the development of drug induced cholestasis 5. This may explain why only some oral AAS users develop the disease and others can endure heavy cycles of alpha alkylated orals. Cholestasis as well as hepatitis caused by non alpha alkylated injectable steroids has been reported, but is rare. Cholestasis can be caused by estrogen as well, both synthetic and endogenous. It is not uncommon for cholestasis to develop during pregnancy, when estrogen levels are high.
It should be stressed that if one develops the symptoms of drug induced cholestasis, the first line of treatment is to immediately discontinue the drug, and begin treatment with UDCA. Although there are no studies showing UDCA exerts any prophylactic effects against AAS induced cholestasis, the proposed mechanism whereby it upregulates hepatic bile transporters suggests it may very well help prevent the disease by increasing bile flow out of the liver.
Once the offending drug is withdrawn, and UDCA therapy begun, the disease typically resolves. UDCA has also been shown to lower both total cholesterol and LDL bad cholesterol via at least two different mechanisms. In one study 6 researchers observed that UDCA lowered the hepatic liver production of cholesterol by interfering with a key enzyme in cholesterol synthesis. In another study, UDCA was administered to animals with moderately elevated cholesterol, somewhat typical of what is seen in many people subsisting on high fat western diets and typical of what is seen in oral AAS users.
When bile enters the digestive tract, a certain portion is reabsorbed, leading to cholesterol reuptake. Dosages of commercial brands of UDCA vary depending on the type and severity of liver disease. For preventative purposes mg per day might be sufficient.
J Am Osteopath Assoc. Ursodeoxycholic acid in cholestatic liver disease: J Pediatr Gastroenterol Nutr. Severe cholestasis with kidney failure from anabolic steroids in a body builder. Expert Opin Drug Saf. The effects of ursodeoxycholic acid on serum and biliary noncholesterol sterols in patients with gallstones. Effect of ursodeoxycholic acid on hepatic LDL binding and uptake in dietary hypercholesterolemic hamsters. Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test.