User Reviews & Ratings - undecylenic acid-zinc undecylenate topicalUndecylenate, or undecylenic acid, is an unsaturated fatty acid with a terminal double bond that is derived undecylenate cvs castor oil. Undecylenic acid undecylenatr also undecylenate cvs naturally in the human sweat. It is used as a precursor in the manufacture of aromatic natural pills for low testosterone, polymers or modified undecylenate cvs [ 6 ]. Undecylenic acid was first isolated from the products of distillation of castor oil in via pyrolysis of ricinoleic acid, and has been polymerized for vinyl production [ 1 ]. It it suggested that many organic fatty acids exert fungicidal or fungistatic actions.
Undecylenate - DrugBank
Undecylenate, or undecylenic acid, is an unsaturated fatty acid with a terminal double bond that is derived from castor oil. Undecylenic acid is also found naturally in the human sweat. It is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones [ 6 ]. Undecylenic acid was first isolated from the products of distillation of castor oil in via pyrolysis of ricinoleic acid, and has been polymerized for vinyl production [ 1 ].
It it suggested that many organic fatty acids exert fungicidal or fungistatic actions. Undecylenic acid also possesses antifungal properties, but is never used on its own for antifungal purposes. Salts of undecylenate are found in topical over-the-counter or mixture products as antifungal agents.
Due to its bifunctional properties, undecylenate is also used as a linking molecule to conjugate other biomolecules such as proteins.
It serves as an acid moiety for anabolic steroid boldenone. Indicated for the treatment of fungal infections as a salt form. No therapeutic indications on its own. Zinc undecylendate acts as a fungistatic agent but fungicidal activity may be observed with chronic exposure in high concentrations [ 5 ].
It is effective against Candida albicans [ 2 , 3 ]. It is proposed that undecylenic acid exerts antimicrobial actions via interacting with nonspecific components in the cell membrane [ 4 ].
Undecylenic acid demonstrated effectiveness against Candida albicans , which is an opportunistic pathogenic yeast with two cellular morphologies: Hyphae formation is associated with active infections and virulence [ 3 ]. A study proposed that undecylenic acid inhibits biofilm formation of Candida albicans with optimal concentration above 3 mM and disrupts hyphal growth, which is the morphological transition from yeast to filamentous phase, at concentration above 4 mM [ 2 ].
Under the drug treatment, hyphal formation related genes, like HWP1, were significantly reduced in transcriptional level leading to poor biofilm formation [ 2 ]. Both biofilm and hyphae formation are critical virulence factors for the initiation of skin infection and late development of disseminated infection [ 2 ].
Undecylenic acid may also inhibit enzyme involved in lipid metabolism and abolish germ tube formation by carrying protons across the plasma membrane, thus altering cytoplasmic pH [ 3 ]. Undecylenic acid may be absorbed through the skin [ MSDS ]. There are no data available on the carcinogenicity, mutagenicity, teratogenicity and developmental toxicity of undecylenate [ MSDS ].
Oral overdosage may lead to gastrointestinal disturbances, and may affect central nervous system excitement, somnolence, muscle contraction or spasticity, headache, dizziness , and metabolism loss of appetite.
Prolonged or repeated exposure to undecylenate may cause anorexia or weight loss [ MSDS ]. Drug created on December 03, Synonyms Not Available Product Ingredients.