EliteFitness.com Bodybuilding ForumsIt shares some similarities with Anavar oxandrolonebut is natural and seems to anavar hormone replacement therapy free of liver-toxic side effects. This article is written for these two kinds of athletes in mind. Dosage of mg per day is the sweet spot, especially when taken transdermally via the skin or when encapsulated in a lipid hherapy the formulator. Higher oral doses ie mg have been reported to cause headaches. This is not reported by transdermal thrapy.
Oxandrolone | Hormone Replacement Therapy clinic of New York.
It shares some similarities with Anavar oxandrolone , but is natural and seems to be free of liver-toxic side effects. This article is written for these two kinds of athletes in mind. Dosage of mg per day is the sweet spot, especially when taken transdermally via the skin or when encapsulated in a lipid by the formulator.
Higher oral doses ie mg have been reported to cause headaches. This is not reported by transdermal users. Contents [ hide ]. In detail, Laxogenin is a sapogenin , a steroidal constituent of the non-sugar portion of a saponin, isolated from the plant Smilax Sieboldii , which is slightly similar to asparagus. However, absorption and bioavailability have held it back from reaching anything near Anavar-like results.
So the real question is — will this work for those of us that are natty or off-cycle , and if so, will it be worth it? Oxandrolone reduces Sex Hormone Binding Globulin SHBG hormones, which promote higher levels of free testosterone and increases nitrogen retention that will leads to anabolism. Oxandrolone has been shown to directly promote lipolysis by binding to androgen receptor, reducing thyroid-binding globulin and enhanced utilization of triiodothyronine T3.
It also increases red blood cell count resulting in an increase in muscular endurance. To be clear l axogenin is not the same as oxandrolone: Laxogenin is plant-based steroid while oxandrolone is chemically synthesized.
Further study is needed on Laxogenin to validate the full effect in the human body, but the extreme success with Anavar may equate to moderate success with laxogenin. There is very little published research directly on Laxogenin. Typically data on oxandrolone or brassinosteroids are used as a proxy for Laxogenin. Interest in Laxogenin took off in when Yahoo Sports! Couch was the former Cleveland Browns QB who was their 1 draft pick in , but was absolutely battered for five painful years and was forced to have multiple shoulder in the mid s.
Unfortunately for us, it would take nearly a decade for a trusted source of laxogenin to come onto the market, since the raw materials in the early s were often accused of being adulterated.
Research in humans on oxandrolone has shown it increases muscle strength and lean body mass, even without exercise. There is also a study of the brassinosteroid, Homobrassinolide HB , in rats which can also be used as a proxy for Laxogenin. The study concluded that HB stimulated protein synthesis and inhibited protein degradation in part by inducing Akt phosphorylation. At time of press, this patent has not been granted, so take these claims with a grain of salt: This is often useful for bodybuilders and heavy weight trainers.
He began taking 3 doses per day of Laxogenin at mg per dose one week prior to knee surgery. He stated his pain had diminished his third day on Laxogenin — 2 days before his operation. The day after his operation the patient was able to discontinue his morphine drip altogether.
He was able to began light walking 3 days after surgery, by the 7th day he could stand and walk far distances free of pain, stiffness and discomfort. He applied a liquid version of Laxogenin topically and reduced surface inflammation and scarring greatly. A 44 year old male with total high cholesterol of LDL reported a significant reduction in total cholesterol levels after a 3 month period using a combination of 7-keto and Laxogenin 5mg 2x daily.
After three months total cholesterol levels were reduced to LDL The patent also has an interesting case study on two Rhodesian Ridgeback dogs who outlived their life expectancy and had a rejuvenating effect, possibly due to Laxogenin, but this is out of the scope of this article.
Looking at the brands we do trust, the reviews effectively state the following:. Taking it further, and realizing that this is mostly for strength gains, Laxogenin is suited best to three types of individuals:. The risk numbers are because there is no long-term research on it, nor is there double-blinded, placebo-controlled research on trained athletes using laxogenin either.
In terms of age , 18 years is the minimum age recommended by brands. Laxogenin seems best applied to athletes, not just guys who want to get big. Oxandrolone has been shown to decrease fat mass in humans. Can its natural counterpart bring moderately similar results?
Since there are minimal to no androgenic side-effects with Laxogenin it should be perfectly fine for women. Furthermore, many women have anecdotally used oxandrolone without issue, which research has recently confirmed with resistance training in women.
The first problem is with adulterated raw material product — back around , there was a surge of laxogenin that…. The solution to that problem is to work with reputable brands who provide third-party test data. Lab tests from raw materials suppliers cannot be trusted. Olympus Labs, whose products are discussed here, conducts third-party high-performance liquid chromatography HPLC testing on all of their compounds.
One such test can be found below:. Although the lab tests for every batch are not available in a public database, Olympus Labs will provide them upon request. Both ingredients have impressive benefits based on mice or rat studies, but anecdotal feedback has shown that some users have responded more favorably while others have experienced little to no benefits.
The ingredient has simply been hit or miss. The first solution is currently the most trusted method, but results are just coming in with new encapsulated forms of laxogenin that may make it easier to take.
Based on the fact that Laxogenin is hindered by a lack of bioavailability, selecting an effective product has been difficult until recently. Even responders to Laxogenin have not seen results close to what was expected from the research. Because of this, the transdermal method is currently the way to go — the only company providing such a product and have released third-party HPLC testing is Olympus Labs , with their DermaStength laxogenin bottle with pump. Due to absorption issues, transdermal 5-Alpha-Hydroxy-Laxogenin is currently the way to go.
Olympus Labs Dermastrength requires half a pump, twice per day, rubbed onto dry skin. With DermaStrength, the entire bottle contains mg worth of laxogenin, and each half -pump represents one serving. Again, it should get pumped onto the arms, shoulders, or stomach. One deviation from this plan is for injured athletes, who could consider rubbing the transdermal gel directly onto their injured areas so long as there are no open cuts.
The trick to improving bioavailability of these compounds is to encapsulate the molecules in a lipid that take far longer to digest and breakdown, ultimately getting more into the bloodstream. This enhanced delivery system allows for greater solubility and enhanced bioavailability, helping to effectively shuttle the active ingredient to the intestines where it can be taken up while preventing degradation throughout the process. On January 5, , Olympus Labs released their latest version: Str3ngth Unleashed , which now uses this new PhytoFuse microencapsulation technology for better absorption!
Combined with creatine, betaine, and a ton of quality food, this is about as aggressive as things are going to get naturally here in Possibly consider the addition of Peak ATP.
Most supplement companies that offer Laxogenin supplements have 25mg of the active ingredient per capsule. The typical dosing recommendations are to consume 1 capsule, times throughout the day, preferably with meals. That would equate to a total of mg per day. Several Laxogenin supplements list a cycle time of weeks. It should be perfectly safe to continue supplementation for longer periods of time. You may want to monitor progress on longer cycles in case your body begins to build up a tolerance to the ingredient, however is not clear whether that is likely.
There are noted side effects in the research on brassinosteroids, nor has there been too serious of anecdotal feedback on Laxogenin supplementation. The worst thing reported are increased headaches when taking high doses ie mg orally. This has not been reported with transdermally applied laxo. Even the steroidal counterpart, oxandrolone, has minimal side effects. Oxandrolone is known as the milder steroids and causes minimal suppression of natural testosterone and growth hormone production.
Therefore, Laxogenin seems to be a safe albeit weaker alternative to harsh pro-hormones if the bioavailability conundrum can be solved.
One study shows a bit of chemistry magic resulting in laxo. Since the study of Homobrassinolide HB in rats suggested there is minimal to no androgenic side-effects, post cycle therapy PCT would not be a requirement. On the flipside, note that many prohormone and steroid users will use laxo during PCT to keep strength up.
It should not conflict with prescription-strength PCT dosing. Government bodies have yet to comment on Laxogenin. Laxogenin has not been added to the FDA list of approved drugs. With that being said there is absolutely no reason to believe that Laxogenin would face any legality issues: Note that oxandrolone is on the the FDA list of approved drugs, so that should alleviate any concerns regarding the legality of Laxogenin.
On paper, Laxogenin seems too good to be true; a plant based steroid that will noticeably increase strength and lean body mass with no androgenic side effects, making it safe for both men and women.
If you fit that mold, it could be worth a shot. So if you decide to invest in a Laxogenin supplement, get the right one, and get after some lifting PRs! PricePlow is a price comparison site that asks one simple question: Laxogenin is also sometimes sold under the name Laxosterone by Genabolix.
Contents [ hide ] 1 What is Laxogenin? What are the reported effects? Are there laxogenin drug tests? Str3ngth Unleashed Now Available 7. How does laxogenin work? What are the laxogenin benefits? Image courtesy Yahoo Sports Research in humans on oxandrolone has shown it increases muscle strength and lean body mass, even without exercise.
Adaptogenic claims The patent applicant claims that laxogenin works in an adaptogenic sense: Synergistic with Anabolic Substances?